Analysis of the IL-1 polymorphism
Especially with smokers, an analysis of the IL-1 polymorphism prior to implantation is urgently recommended, since these patients have to reckon to 50 % with implant failure or significant biological complications such as higher attachment loss if they carry the respective gene modifications. According to studies by Laine et al., also a variation in the IL-1RN-encoding gene is associated with an increased susceptibility to peri-implantitis and therefore represents a risk factor. Thus, an analysis of the IL-1 polymorphism (e.g. GenoType IL-1) may be a valuable aid in determining the therapeutic regimen.