Active ingredient group: Nitroimidazoles
Mechanism of action: Induces strand breaks in bacterial DNA, thereby inhibiting nucleic acid synthesis. Bactericidal.
Contraindication: CNS disorders, pregnancy, hypersensitivity, lactation, severe liver damage, children under 6 years of age.
Interactions: Possible interactions with oral anticoagulants such as warfarin, lithium preparations, disulfiram, barbiturates, phenytoin, cimetidine.
Side effects: Gastrointestinal disturbances, headache, peripheral neuropathy, metallic taste, central nervous system disturbances, reversible neutropenia, discolored urine, inability to tolerate alcohol.
Use in the context of periodontal therapy: Agent of choice where red, orange and orange-associated complex bacteria are identified